Fentanyl Addiction Recovery: Side Effects, Withdrawal & Detox Options

Fentanyl is a very powerful prescription opioid pain medication that is prescribed for severe acute or chronic pain. When misused, it’s a potentially dangerous medication that can cause serious adverse health effects, including addiction and overdose.1 Synthetic (man-made) opioids (mainly fentanyl) accounted for almost 73% of opioid-involved deaths and 51% of total overdose deaths in 2019.2, 3
About Fentanyl

What is Fentanyl & How Is it Used?

fentanyl in a hospital settingFentanyl is a very potent synthetic opioid that is an estimated 50 to 100 times stronger than morphine. It’s sometimes prescribed to people suffering from severe post-operative or cancer pain.1

When prescribed, it’s common for fentanyl to be dispensed in lollipop form. The dissolving lozenge can be quickly absorbed through the cheeks and under the tongue for quick relief from breakthrough pain (i.e., pain that is so severe it renders most painkillers ineffective).1, 4

For chronic pain, fentanyl can be administered via transdermal patch. The patch releases the drug slowly into the skin over 72 hours.1, 5

In medical facilities, fentanyl is administered intravenously, often in combination with a benzodiazepine, for sedation and pain prevention before procedures like oral surgery and endoscopy.6 Other preparations include tablets, nasal sprays, and inhalers.7

When fentanyl is purchased illegally as a street drug, it is often manufactured in an illicit laboratory and can be laced with other chemicals or drugs which can make fentanyl that much more dangerous.8 Often the user does not know the exact ingredients or dosage when purchasing fentanyl on the street which can increase the chance of overdose, even after one use.

Fentanyl can be:1, 9

  • Injected.
  • Taken orally.
  • Snorted (often when it appears as an additive in other substances like cocaine).
  • Smoked.

Is Fentanyl Addictive?

As a powerful opioid, fentanyl has a high addiction potential for both medical and recreational users, specifically when it is misused. Those who have been using fentanyl according to doctor’s recommendations will often need to be weaned off the medication in order to avoid withdrawal symptoms and cravings.1

Fentanyl addiction often requires medication-assisted treatment (MAT) in combination with therapy and social support programs to help someone be successful on their recovery journey.10

How Fentanyl Abuse Starts

Someone may begin misusing fentanyl after they were prescribed the drug, while others may start using fentanyl just for its euphoric effects.1

Abuse of a prescription drug is defined as any use beyond that approved by the doctor. The definition of misuse of prescription fentanyl includes:11

  • Taking someone else’s prescription.
  • Taking fentanyl to feel euphoria (as opposed to pain relief).
  • Using fentanyl in a way in which it was not prescribed (e.g., smoking fentanyl, taking it more frequently than prescribed, taking a higher dose than prescribed).

People that use other drugs may use fentanyl unknowingly, as it is commonly added to other street drugs, which gravely increases the risk of overdose. The practice of cutting other drugs (like heroin, cocaine, counterfeit prescription pills, etc.) with fentanyl is becoming increasingly common.1, 9

Health Effects & Risks

What Are the Long-Term Effects of Fentanyl Abuse?

Fentanyl shares the same long-term dangers as many other opioids, such as heroin or oxycodone. These include:12

  • Decreased libido.
  • Depression.
  • Chronic constipation, which can cause bowel obstructions.
  • Weakened immune system.
  • Respiratory problems caused by reduced breathing.
  • Increased risk of heart attack.
  • Brain damage from diminished oxygen to the brain.

Many people that use fentanyl do so by intravenous injection. There are very serious health risks associated with needle drug use specifically, including:

  • Skin abscesses.
  • Infectious disease spread by sharing needles (e.g., HIV/AIDS, Hepatitis C, etc.).
  • Endocarditis (infection of the inner lining of the heart and heart valves).

Risks of Mixing Fentanyl with Other Drugs

Using fentanyl and other drugs simultaneously is incredibly dangerous. The risks of fentanyl abuse are heightened by the negative health effects of other drugs.1

As mentioned above, fentanyl, which is relatively cheap to produce, is often added to other drugs to make them appear stronger. In many cases, someone may not even be aware they are using fentanyl-laced drugs.1

Signs of Abuse

How to Know if Someone is Abusing Fentanyl

Someone that is misusing prescription fentanyl may:15

  • Frequently try to refill their prescription early.
  • Try to fill a prescription for fentanyl at multiple pharmacies.
  • Be uninterested in suggestions for non-opioid medications.
  • Complain of symptoms despite their condition improving.

Addiction to fentanyl—also known as opioid use disorder (OUD)—is a medical condition that should be diagnosed by a healthcare professional. Addiction occurs when an individual cannot cut back or quit fentanyl (or other drug or alcohol) use despite the negative consequences on their lives and others around them.

The negative repercussions often include financial trouble, strained relationships, poor work/school performance, trouble with the law, and negative behavioral changes. Addiction rewires the brain to the extent that thought patterns and behaviors change, resulting in the compulsive need to obtain more of the drug, despite these negative consequences.

Detox & Treatment

Detoxing from Fentanyl

Fentanyl withdrawal is seldom life-threatening, but it is often very unpleasant and painful, which may lead someone to relapse quickly. Acute withdrawal from fentanyl and other short-acting opioids typically last between 3 and 5 days.17, 18

Medically assisted detox can make the fentanyl withdrawal process safer and more comfortable. During medical detox, staff can respond to emergencies and administer medication to ease cravings and withdrawal symptoms.1, 17

Fentanyl withdrawal symptoms often include:1, 17

  • Muscle and bone pain.
  • Sweating.
  • Stomach pains.
  • Irritability.
  • Depressed mood.
  • Vomiting.
  • Diarrhea.

While detox is often a necessary step in entering recovery from a fentanyl addiction, detox on its own is rarely effective without continued treatment.10

Rehabilitation Treatment for Fentanyl Addiction

Opioid use disorder—like all substance use disorders—is a chronic but treatable medical condition. There are several ways to treat addiction, and the most effective option varies according to the patient’s needs. However, each form of addiction treatment typically involves various types of therapy and, often the use of medication.10

Rehabilitation treatment can be provided in a variety of settings. For example, in addition to medical detox, Oxford Treatment Center offers:

  • Residential treatment.
  • Partial hospitalization (day treatment).
  • Intensive outpatient treatment.
  • Outpatient care.

These forms of addiction treatment are covered by most insurance plans. Our will reveal if a specific insurance plan provides coverage at Oxford Treatment facility.

Medication-assisted treatment (MAT) often begins during detox and may continue for months or even years afterward. Certain medications are administered to  ease withdrawal symptoms, mitigate cravings, and discourage relapse.19, 20

Therapy—during and after rehab—helps patients build the skills necessary to remain in recovery. This includes:21

  • Engaging and motivating them to remain in recovery.
  • Adjusting their attitudes toward drug use.
  • Identifying, avoiding, and overcoming triggers that lead them to use fentanyl.
  • Altering thought and behavioral patterns.
  • Learning how to form and repair positive interpersonal relationships.

After rehab, many people in recovery benefit from an aftercare program, such as staying in a sober-living facility or joining a 12-step peer-support program. Recovery is a life-long process, and continuing care helps people remain focused and maintain a positive network of peer support that is conducive to sobriety.22

You don’t have to do it alone; help is just a call away. Call us at and we can help you find the right rehab program for you or your loved one. Whether you choose to attend our drug addiction treatment program in Mississippi at Oxford Treatment Center or at one of American Addiction Centers’ other rehab facilities across the United States, we will be there with you at every step of the way.